Drug particles are coated using a combination of coacervation (phase separation) and spray coating to build polymeric membranes of varying porosity and thickness. The layers employ a gastro-soluble pore-former (organic, inorganic, or polymeric), which cannot be dissolved by saliva and blocks bitter drug taste. The pore-former rapidly dissolves in the stomach for fast drug release, enhancing the probability of achieving bioequivalence to an immediate release (IR) reference listed drug (RLD).
Taste Masking and ODTs
Taste Masking Technology
Precisely and uniformly coated individual drug particles deliver a smooth, pleasant mouthfeel, with no aftertaste. This improves product acceptability and patient adherence.