Biorise™ Bioavailability Enhancement Technology
This technology creates new physical entities (NPEs) with better solubility profiles. These NPEs are produced by breaking down the crystalline drug into nanocrystals and/or amorphous (non-crystalline) drug particles that are stabilized in a carrier system to maintain the drug in its activated form for the duration of its shelf life.
This approach transforms the original crystalline form of the drug into an amorphous and/or nanocrystalline, thermodynamically activated solid form—characterized by higher solubility—thereby enhancing the rate and extent of absorption in the gastrointestinal tract.
Advantages of BioriseTM Bioavailability Enhancement Technology
- Can be applied to class II compounds with solubilities in the range of <10 to 500 μg/mL
- May provide a faster onset of action, equivalent therapy at lower doses, and/or oral dosing of poorly soluble drugs, as well as reduced food effect for poorly soluble drugs
Two distinct proprietary activation systems are available to create NPEs—high-energy mechano-chemical activation (HEMA) and solvent-induced activation (SIA). These systems convert drugs to their thermodynamically activated state. Additionally, they provide flexibility and enable the technology to be applied to a range of compounds with different characteristics.