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Bioavailability Enhancement

Diffucaps® (Solid-Solution or Solid-Dispersion) Bioavailability Enhancement Technology

In this application, Diffucaps® technology enables the development of novel, solubility-enhanced, amorphous, solid-solution/solid-dispersion formulations of drugs that exhibit poor solubility in physiological fluids.

Diffucaps® is a multiparticulate bead system made up of multiple layers of drug, excipients, and release-controlling polymers. The beads can contain a solid-solution/solid-dispersion drug form and crystallization inhibitor to enhance bioavailability by maintaining the drug in its amorphous state. The solubility-enhanced beads can be coated with one or more functional polymers to achieve extended-release profiles suitable for once- or twice-daily dosing regimens.